Study could spur wider use of prenatal gene tests

A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.

A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.

"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."

He led the federally funded study, published in Thursday's New England Journal of Medicine.

A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.

The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.

"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.

Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.

The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.

The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.

In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.

"Some did it for anxiety — they just wanted more information about their child," Wapner said.

Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.

"That's a lot. That's huge," Klugman said.

Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.

Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.

In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.

Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.

"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.

"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.

The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.

The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.

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Medical journal: http://www.nejm.org

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Obama Rejects GOP 'Doomsday' Plan

President Obama's lead negotiator in the "fiscal cliff" talks said the administration is "absolutely" willing to allow the package of deep automatic spending cuts and across-the-board tax hikes to take effect Jan. 1, unless Republicans drop their opposition to higher income tax rates on the wealthy.

Treasury Secretary Timothy Geithner said in an interview with CNBC that both sides are "making a little bit of progress" toward a deal to avert the "cliff" but remain stuck on Obama's desired rate increase for the top U.S. income-earners.

"There's no prospect for an agreement that doesn't involve those rates going up on the top two percent of the wealthiest," Geithner said.

Most House Republicans, including Speaker John Boehner, remain opposed to any increase in tax rates.

Obama and Boehner spoke by phone this afternoon, their first conversation in exactly one week, an administration official said. Their relations have grown frosty in recent days as both sides have dug in on the issue of higher rates.

In separate appearances earlier today, Obama and Boehner publicly sparred over who's to blame for the standoff and what to do if lawmakers can't reach a broad deficit-reduction agreement in 27 days.

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Obama, speaking at a meeting of 100 CEOs, warned Republicans that he would not accept a so-called "doomsday" deal that extends tax cuts for middle-income earners before the end of the year but nothing more.

Such an approach, which has been under consideration by top Republicans as a likely scenario, would set the stage for a big battle over spending cuts and top tax rates in early 2013 – all tied to the nation's debt ceiling, which will need to be raised, which only Congress can do.

"That is a bad strategy for America, it's bad strategy for businesses," Obama said. "It's not a game I will play."

Brinksmanship over the a 2011 debt ceiling increase to avoid a U.S. default cost the country its AAA credit rating and rattled markets around the world.

While both sides say publicly that the U.S. will not default on its debt obligations, Republicans believe the issue could give them increased leverage for extracting cuts to entitlement programs and other spending.

Boehner said at a morning news conference that Obama has stifled the "fiscal cliff" negotiations by imposing the precondition that Republicans accept income tax hikes on the top 2 percent of U.S. earners.

"We're ready and eager to talk to the president and to work with him to make sure that the American people aren't disadvantaged by what's happening here in Washington," Boehner said at a morning news conference.

"We need a response from the White House," he said. "We can't sit here and negotiate with ourselves."

Earlier this week, House Republicans presented a $2.2 trillion deficit reduction package, including $800 billion in higher taxes through elimination of loopholes and deductions, slower annual cost-of-living increases for Social Security benefits and a higher eligibility age for Medicare.

The plan contrasts sharply with the White House proposal, which calls for $1.6 trillion in new tax revenue -- largely from higher rates on upper-income earners -- modest unspecified savings from Medicare and a new burst of economic stimulus spending.

Both sides rejected the opposing plan as "unserious."

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NATO warns Syria not to use chemical weapons

BRUSSELS/BEIRUT (Reuters) - NATO told Syrian President Bashar al-Assad on Tuesday that any use of chemical weapons in his fight against encroaching rebel forces would be met by an immediate international response.

The warning from NATO Secretary-General Anders Fogh Rasmussen came as U.S. government sources said Washington had information that Syria was making what could be seen as preparations to use its chemical arsenal.

Syrian forces meanwhile bombarded rebel districts near Damascus in a sustained counter-attack to stem rebel gains around Assad's power base as the insurgency may be entering a decisive phase.

International concern over Syria's intentions has been heightened by reports that its chemical weapons have been moved and could be prepared for use.

"The possible use of chemical weapons would be completely unacceptable for the whole international community and if anybody resorts to these terrible weapons I would expect an immediate reaction from the international community," Rasmussen told reporters at the start of a meeting of alliance foreign ministers in Brussels.

The chemical threat made it urgent for the alliance to send Patriot anti-missile missiles to Turkey, Rasmussen said.

The French Foreign Ministry referred to "possible movements on military bases storing chemical weapons in Syria" and said the international community would react if they were used.

Britain has told the Syrian government that any use of chemical weapons would have "serious consequences", Foreign Secretary William Hague said.

U.S. President Barack Obama on Monday told Assad not to use chemical weapons, without saying how the United States might respond. The Foreign Ministry in Damascus said it would never use such weapons against Syrians.

CLASSIFIED INTELLIGENCE

The U.S. has collected what has been described as highly classified intelligence information demonstrating that Syria is making what could be construed as preparations to use elements of its extensive chemical weapons arsenal, two U.S. government sources briefed on the issue said.

One of the sources said that there was no question that the US "Intelligence community" had received information pointing to "preparations" under way in Syria related to chemical weapons. The source declined to specify what kind of preparations had been reported, or how close the intelligence indicated the Syrians were to deploying or even using the weapons.

Western military experts say Syria has four suspected chemical weapons sites, and it can produce chemical weapons agents including mustard gas and sarin, and possibly also VX nerve agent. The CIA has estimated that Syria possesses several hundred liters of chemical weapons and produces hundreds of tonnes of agents annually.

The fighting around Damascus has led foreign airlines to suspend flights and prompted the United Nations and European Union to reduce their presence in the capital, adding to a sense that the fight is closing in.

The army fightback came a day after the Syrian foreign ministry spokesman was reported to have defected in a potentially embarrassing blow to the government.

The Syrian Observatory for Human Rights said 200 people were killed across Syria on Monday, more than 60 of them around Damascus. Assad's forces bombarded districts to the south-east of the capital on Tuesday, near to the international airport, and in the rebel bastion of Daraya to the south-west.

Opposition footage posted on the Internet showed a multiple rocket launcher fire 20 rockets, which activists said was filmed at the Mezze military airport in Damascus.

Reuters could not independently verify the footage due to the government's severe reporting restrictions.

In central Damascus, shielded for many months from the full force of a civil war in which 40,000 people have been killed, one resident reported hearing several loud explosions.

"I have heard four or five thunderous blows. It could be barrel bombs," she said, referring to makeshift bombs which activists say Assad's forces have dropped from helicopters on rebel-dominated areas.

MORTAR ATTACK

The state news agency said that 28 students and a teacher were killed near the capital when rebels fired a mortar bomb on a school. Rebels have targeted government-held residential districts of the capital.

The mainly Sunni Muslim rebel forces have made advances in recent weeks, seizing military bases, including some close to Damascus, from forces loyal to Assad, who is from Syria's Alawite minority linked to Shi'ite Islam.

Faced with creeping rebel gains across the north and east of the country, and the growing challenge around the capital, Assad has increasingly resorted to air strikes against the insurgents.

A diplomat in the Middle East said Syrian Foreign Ministry spokesman Jihad Makdissi had left the country and defected, while the British-based Observatory said it had information that he flew from Beirut on Monday afternoon heading for London.

In Beirut, a diplomat said Lebanese officials had confirmed that Makdissi spent several days in Beirut before leaving on Monday, but could not confirm his destination.

"We're aware of reports that he has defected and may be coming to the UK. We're seeking clarification," a Foreign Office spokeswoman in London said.

Makdissi was the public face to the outside world of Assad's government as it battled the 20-month-old uprising. But he had barely appeared in public for several weeks before Monday's report of his defection.

He had little influence in a system largely run by the security apparatus and the military. But Assad's opponents will see the loss of such a high profile figure, if confirmed, as further evidence of a system crumbling from within.

The United Nations and European Union both said they were reducing their presence in Syria in response to the escalated violence around the capital.

A spokesman for U.N. humanitarian operations said the move would not stop aid deliveries to areas which remained accessible to relief convoys.

"U.N.-funded aid supplies delivered through SARC (Syrian Arab Red Crescent) and other charities are still moving daily where the roads are open," Jens Laerke told Reuters in Geneva.

"We have not suspended our operation, we are reducing the non-essential international staff."

Three remaining international staff at the European Union delegation, who stayed on in Damascus after the departure of most Western envoys, crossed the border into Lebanon on Tuesday after pulling out of the Syrian capital.

(Additional reporting by David Brunnstrom in Brussels, Khaled Yacoub Oweis in Cairo, Erika Solomon, Oliver Holmes and Ayat Basma in Beirut, Mark Hosenball, Mohammed Abbas and David Cutler in London, and Stephanie Nebehay in Geneva; Editing by Giles Elgood)

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Football: Real Madrid hit four as Ajax crumble

MADRID: Real Madrid made light work of Ajax with an emphatic 4-1 win on Tuesday, but still had to settle for second place in Champions League Group D.

Goals from Cristiano Ronaldo, Kaka and a Jose Callejon double in the Santiago Bernabeu sealed the Spanish champions' victory, but top spot in the group went to Borussia Dortmund who beat Manchester City 1-0.

Derk Boerrigter got the consolation for the Dutch who gave a good account of themselves and their reward is a place in the Europa League after finishing third ahead of Manchester City, who came a miserable last.

Afterwards Madrid coach Jose Mourinho was full of praise for the performance of ex-Tottenham player Luka Modric, who gave two wonderful assists for his side's first goals of the evening.

"Modric has already performed well for us in a number of games, he is a great player who can play at the highest level, nobody can deny he is going to be an important signing for the future of this club," he said.

Mourinho had earlier took advantage of having already qualified to rest a number of first team players, mixing youth with experience, a tactic for which he has recently come under fire in the Spanish press for rarely doing.

Reserve goalkeeper Adan started and a Champions League debut was handed to full-back Nacho Fernandez.

Mourinho also introduced 17-year-old Jose Rodriguez and Alvaro Morata, a year his elder, late on while the experienced Ricardo Carvalho started his first Champions League game of the season.

Fabio Coentrao limping off early, with what looked like a hamstring injury, was the only negative on the night for Mourinho.

Ajax coach Frank de Boer, with a Europa League place still to fight for, named the same side that began Saturday's encouraging 3-1 win over PSV Eindhoven.

However, the weakened Madrid side did not appear to be worried as they dominated possession and it was not long before the chances began arriving thick and fast.

Karim Benzema had the ball in the net as early as the seventh minute but the French striker was ruled offside.

By the time Cristiano Ronaldo hit Madrid's first of the night on 13 minutes, a post had already come between Fabio Coentrao and the opening goal.

Modric won the ball in his own half before finding Benzema with a long raking pass that allowed the Frenchman to check back and square the ball into the path of Ronaldo for an easy finish.

Kenneth Vermeer in the Ajax goal had to make good saves from Benzema and Ronaldo before Callejon doubled Real's lead on 28 minutes.

Modric was again involved, turning under pressure on halfway before digging out a fantastic pass for Callejon to race onto and finish with aplomb.

A Sami Khedira shot on 39 minutes had to be dealt with by Vermeer, and it was his performance that kept Madrid's lead down to two at the break.

For Ajax, 18-year-old Dane Viktor Fischer was lively all evening on the left wing and he brought the first save of the night from Adan just before the interval.

Kaka hit Madrid's third, exquisitely curling a left-footed shot home off the post from just outside the area just after the break.

Ajax then enjoyed a good period of pressure and much needed relief.

Fischer went close with a curling shot before Derk Boerrigter pounced on a punched clearance from Adan to grab a consolation for the Dutch on the hour mark.

Boerrigter forced a save from Adan with a free-kick five minutes later and Ajax went on to play bright attacking football for much of the second half.

Mourinho shuffled his pack and introduced youth and Morata responded with a great run on the right and cross for Callejon to head home his second and his side's fourth with two minutes remaining.

- AFP/fa

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Cash scheme will influence polls, says CEC

CHENNAI/NEW DELHI: Chief election commissioner V C Sampath on Tuesday expressed his disapproval over the Centre's decision to go ahead with the direct cash transfer scheme when assembly elections were round-the-corner in Gujarat.

Himachal Pradesh, the other state that went to polls, is yet to know the result, and model code of conduct is still in force.

Sampath, who was in Chennai to review the ongoing summary revision of rolls, said that the EC would not allow the level playing field to be disturbed in any manner. He said the Centre should not have started the scheme at this juncture. "Our order is clear, that it is something which ought not to have been done now." The scheme will actually come into effect only on January 1, but the EC's view is that the announcement should not have been made now as it would influence elections in the two states. "We have expressed our concern," he added.

The CEC has also directed the Centre to suspend all steps towards operationalization of the scheme in the two election-bound states until the poll process was complete. Incidentally, this may make little difference on the ground as the direct cash transfer scheme is to roll out across 51 districts — of which four are in Gujarat and two in Himachal Pradesh — only from January 1, 2013. The poll process in the two states will wind up by December 24.

TOI was the first to report on December 2 about EC's unhappiness over the timing of the cash transfer scheme and said its implementation would be put on hold in the poll-bound states until after the elections.

The EC's order on Tuesday, which followed a BJP complaint, said the poll-eve announcement was "avoidable... going by the letter and spirit of the model code of conduct".

Stating that the commission was not going into the merits of the government's policy decisions but was concerned if any such decision would disturb the electoral level playing field, the EC said the government had failed to offer justification sought by it on the necessity of the direct cash transfer announcement while the poll code was in force in Gujarat and Himachal.

The three-member body is said to have questioned the urgency behind announcing the scheme in November when the roll out was slated only by the New Year, by when the poll process would be over.

Besides, the fact that two Union ministers, P Chidambaram and Jairam Ramesh, held forth on the benefits of the scheme from Congress platforms caught the EC's attention. The government sees cash transfers as a major poll hook, coining the slogan "aap ka paisa, aap ke haath" while seeing the benefits of the scheme in streamlining subsidies and getting rid of ghost beneficiaries. Mindful of its populist appeal, the BJP lost no time in alleging violation of the poll code by the Congress-led government at the Centre.

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Study: Drug coverage to vary under health law

WASHINGTON (AP) — A new study says basic prescription drug coverage could vary dramatically from state to state under President Barack Obama's health care overhaul.

That's because states get to set benefits for private health plans that will be offered starting in 2014 through new insurance exchanges.

The study out Tuesday from the market analysis firm Avalere Health found that some states will require coverage of virtually all FDA-approved drugs, while others will only require coverage of about half of medications.

Consumers will still have access to essential medications, but some may not have as much choice.

Connecticut, Virginia and Arizona will be among the states with the most generous coverage, while California, Minnesota and North Carolina will be among states with the most limited.

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Obama Sees 'Potential' for Averting the Fiscal Cliff

President Obama says he sees "potential" for averting the "fiscal cliff" in 28 days, but that no deal will get done unless Republicans consent to raise income-tax rates on the top 2 percent of U.S. earners.

"We're going to have to see the rates on the top 2 percent go up and we're not going to be able to get a deal without it," Obama told Bloomberg TV in his first televised interview since the Nov. 6 election.

Obama suggested that Republican opposition to any increase in tax rates has stifled progress in negotiations and at least partly explains why he has not met more regularly with House Speaker John Boehner.

"Speaker Boehner and I speak frequently," he said. "I don't think the issue right now has to do with sitting in a room.

"Unfortunately, the speaker's proposal right now is still out of balance," he added, referring to the GOP plan unveiled Monday that would extend all income tax rates at current levels while imposing changes to Medicare and Social Security.

The GOP proposal would achieve $2.2 trillion in deficit reduction in the next decade, including $800 billion in higher taxes through elimination of loopholes and deductions, slower annual cost-of-living increases for Social Security benefits and a higher eligibility age for Medicare.

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The plan contrasts sharply with the White House proposal, which calls for $1.6 trillion in new tax revenue -- largely from higher rates on upper-income earners -- modest unspecified savings from Medicare and a new burst of economic stimulus spending.

Both sides have dismissed out of hand the opposing proposal, raising the prospect of continued gridlock as the economy hurdles toward the "cliff."

Income tax rates for the top 2 percent of Americans remain the immediate sticking point. Obama insists that rates must rise at the end of the year as part of any deal; Republicans oppose increasing rates on the wealthy.

Unless Obama and Republicans reach a compromise, a sweeping set of automatic, across-the-board tax hikes and deep spending cuts will take effect, potentially throwing the U.S. economy back into recession.

The "cliff" scenario results from a failure by Congress and the administration at previous intervals to take steps to reduce federal deficits and debt.

In the Bloomberg interview, Obama said he could be flexible on tax rates and entitlement overhaul, but only in broader discussions next year about revamping the tax code and social safety-net programs.

"Let's let [rates on higher-income earners] go up and then let's set up a process with a time certain at the end of 2013, or the fall of 2013, where we work on tax reform, we look at what loopholes and deductions both Democrats and Republicans are willing to close and it's possible that we may be able to lower rates by broadening the base at that point," he said.

The president also said he's "willing to look at anything" that might strengthen entitlements and extend their financial solvency, but did not specify further.

Republicans continued to rebuff the president's proposal Tuesday, claiming the $1.6 trillion package of tax increases could not pass either house of Congress, including the Democrat-controlled Senate.

"Only one person in the country can deliver the members of his party to support a deal that he makes, and that is the president," said Senate Minority Leader Mitch McConnell.

He praised House Republicans for "trying to move the process forward" with their proposal, but stopped short of endorsing it. Some conservative advocacy groups have been assailing GOP leaders this week for consenting to any tax revenue increases in a deal with Obama.

"With our latest offer we have demonstrated there is a middle ground solution that can cut spending and bring in revenue without hurting American small businesses," Boehner said in a statement today.

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Israel says will stick with settlement plan despite condemnation

JERUSALEM (Reuters) - Israel rejected concerted criticism from the United States and Europe on Monday over Prime Minister Benjamin Netanyahu's decision to expand settlement building after the United Nations' de facto recognition of Palestinian statehood.

Washington urged Israel to reconsider its plan to erect 3,000 more homes in the occupied West Bank and East Jerusalem, saying the move hindered peace efforts with the Palestinians.

Britain, France, Spain, Sweden and Denmark summoned the Israeli ambassadors in their capitals to give similar messages.

An official in Netanyahu's office said Israel would not bend. "Israel will continue to stand by its vital interests, even in the face of international pressure, and there will be no change in the decision that was made," the official said.

Angered by the U.N. General Assembly's upgrading on Thursday of the Palestinians' status in the world body from "observer entity" to "non-member state", Israel said the next day it would build the new dwellings for settlers.

Such projects, on land Israel captured in a 1967 war, are considered illegal by most world powers and have routinely drawn condemnation from them. Approximately 500,000 Israelis and 2.5 million Palestinians live in the two areas.

In a shift that raised the alarm among Palestinians and in world capitals, Netanyahu's pro-settler government also ordered "preliminary zoning and planning work" for thousands of housing units in areas including the "E1" zone east of Jerusalem.

Such construction in the barren hills of E1 has never been put into motion in the face of opposition from Israel's main ally, the United States. Building in the area could bisect the West Bank, cut off Palestinians from Jerusalem and further dim their hopes for a contiguous state.

Israeli television stations reported Jerusalem's district planning commission would soon approve plans for several thousand more housing units, including more than 1,000 Israel had shelved two years ago after angering Washington by publishing the plans before a visit by Vice President Joe Biden.

The settlement plan, U.N. Secretary-General Ban Ki-moon said, would deal "an almost fatal blow" to a two-state solution to the Israeli-Palestinian conflict.

French President Francois Hollande said he was "extremely concerned" and Washington made clear it would not back such Israeli retaliation over the U.N. vote, sought by Palestinians after peace talks collapsed in 2010 over settlement building.

"We urge Israeli leaders to reconsider these unilateral decisions and exercise restraint as these actions are counterproductive and make it harder to resume direct negotiations to achieve a two state solution," White House spokesman Jay Carney told a briefing.

Ahead of a Netanyahu visit this week, Germany, considered Israel's closest ally in Europe, urged it to refrain from expanding settlements, and Russia said it viewed the Israeli moves with serious concern.

RETALIATION

Israeli Finance Minister Yuval Steinitz said Israel could not have remained indifferent to the Palestinians' unilateral move at the United Nations.

"I want to tell you that those same Europeans and Americans who are now telling us 'naughty, naughty' over our response, understand full-well that we have to respond, and they themselves warned the Palestinian Authority," he said.

Palestinian chief negotiator Saeb Erekat said building in E1 "destroys the two-state solution, (establishing) East Jerusalem as the capital of Palestine and practically ends the peace process and any opportunity to talk about negotiations in the future".

The United States, one of the eight countries to vote alongside Israel against the Palestinian resolution at the General Assembly, has said both were counterproductive to the resumption of direct peace talks.

In Europe, only the Czech Republic voted against the status upgrade while many countries, including France, backed it. Netanyahu plans to visit Prague this week to express his thanks.

In the Gaza Strip, Sami Abu Zuhri, spokesman for the governing Hamas Islamist movement, called the settlements "an insult to the international community, which should bear responsibility for Israeli violations and attacks on Palestinians".

Israeli police arrested three Jewish settlers on Monday whom they suspect of arson and other crimes against Palestinian property in the West Bank, including the torching of a car.

Attackers have often proclaimed they are exacting a "price tag" for steps taken against the settler movement by Palestinians, or by the Israeli government.

Alongside the settlement plans, Israel announced it would withhold about $100 million in Palestinian tax revenues from the Palestinian Authority, which exercises limited self-rule in the West Bank, saying Palestinians owed $200 million to Israeli firms.

"These are not steps towards peace, these are steps towards the extension of the conflict," Spanish Foreign Minister Jose Manuel Garcia-Margallo said.

Only three weeks ago, Netanyahu won strong European and U.S. support for a Gaza offensive that Israel said was aimed at curbing persistent cross-border rocket fire.

Favored by opinion polls to win a January 22 national election, he brushed off the condemnation and complaints at home that he is deepening Israel's diplomatic isolation.

Netanyahu told his cabinet on Sunday that his government "will carry on building in Jerusalem and in all the places on the map of Israel's strategic interests".

But while his housing minister has said the government would soon invite bids from contractors to build 1,000 homes for Israelis in East Jerusalem and more than 1,000 in West Bank settlement blocs, the E1 plan is still in its planning stages.

"No one will build until it is clear what will be done there," the minister, Ariel Attias, said on Sunday.

Israel froze much of its activities in E1 under pressure from former U.S. President George W. Bush, and the area has been under the scrutiny of his successor, Barack Obama.

Israel cites historical and Biblical links to the West Bank and Jerusalem and regards all of the holy city as its capital, a claim that is not recognized internationally.

(Additional reporting by Crispian Balmer, Dan Williams, Nidal al-Mughrabi in Gaza, Jihan Abdalla in Ramallah, Steve Gutterman in Moscow, Gareth Jones in Berlin, John Irish and Elizabeth Pineau in Paris and Tim Castle in London; writing by Jeffrey Heller; editing by Philippa Fletcher)

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Football: Lionel Lewis calls it a day

SINGAPORE: He was Singapore's safest pair of hands for almost a decade and, despite retiring from international football last year with 73 caps, Lionel Lewis was playing well enough to warrant consideration for a recall to the national squad for the current ASEAN Football Federation Championship.

But a persistent ankle injury put paid to the possibility of that happening, and now Lewis has decided to call it a day.

The 29-year-old Home United custodian will hang up his gloves to get a head start on his post-football career at Nanyang Polytechnic, his former school. He will be joining its Student Affairs Department.

"My friends and family know I have been thinking about my career after football," said Lewis, who had a training stint with Manchester City in 2007 and a week-long trial with Swiss side Grasshopper-Club Zurich.

"The job offer from Nanyang Polytechnic has been on the table for several months and after working out all the options, including the possibility of playing football on a part-time basis, I've decided to stop instead when my contract with Home runs out at the end of this month."

With a young family - his wife Jenny gave birth to their son Jonas only 10 weeks ago and his daughter Jennel is four - Lewis, who has a Sports Management degree from the University of Wolverhampton, felt it was necessary to not delay the start of his second career.

"I can play for another five to eight years, and if I were getting the kind of money that an English Premier League player earns, maybe it would be harder to walk away. But a footballer's pay here... you can't even smell their one-week wages," said Lewis, who did not say how much he earned at Home.

"I'm not putting down local football but that is the reality. Getting started now means that when I am 35, I can have a more assured career and hopefully be able to explore more options."

Former Singapore and Home United coach P N Sivaji thinks Lewis is making the right move.

"Yes, Lionel's one of our best goalkeepers ever, and yes, keepers do get better with age. But I think he's probably tired of the life of a footballer and its routines," he said.

Lewis' 12-year playing career has left him with a litany of injuries. He even had surgery three weeks ago to repair a tear to his anterior talofibula ligament. But he said he was not quitting because of his injuries.

"I've got to be satisfied with my 12 years, having won many trophies and travelled to most parts of the world," he said. "It has been an absolutely wonderful journey, and I am looking forward to this career change.

"I still plan to play football once a week and my friends will be happy because I can now join their social games."

- TODAY

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Zee editors denied bail for 2nd time in a week

NEW DELHI: For the second time in less than a week, a trial court on Monday dismissed the bail applications of the two Zee group editors arrested for allegedly trying to extort Rs 100 crore from Congress MP Naveen Jindal's firm.

Metropolitan magistrate Rajinder Singh on Monday dismissed the bail pleas, saying Zee News head Sudhir Chaudhary and Zee Business editor Samir Ahluwalia had not given any new grounds for their release on bail after their earlier plea was rejected on November 28. The two editors will now have to move a higher court for bail.

Move higher court for bail: Magistrate

Investigation is at a preliminary stage and there is no change of facts and circumstances since November 28...and no fresh ground has come up to release them on bail. Hence, in my considered opinion, the bail (plea) is dismissed," the court said while dismissing bail pleas of two Zee group editors. The metropolitan magistrate said the two editors would now have to move a higher court for bail.

During the hearing, special public prosecutor Rajiv Mohan argued that the two accused had no right to move a fresh bail plea as a similar application under section 437 of CrPC had been dismissed by a magistrate.

Mohan argued the two editors should not be given bail as they were involved in criminally extorting money from Jindal Steel and Power Limited and have also abused the freedom of speech and expression granted to the press under Article 19 of the Constitution. The two had been booked for non-bailable offences and hence can't be released on bail, Mohan added.

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